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KMID : 0380620210530020223
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Korean Journal of Food Science and Technology
2021 Volume.53 No. 2 p.223 ~ p.229
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Protective effect of Codium fragile extract on fine dust (PM2.5)-induced toxicity in nasal cavity, lung, and brain cells
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Kim Gil-Han
Park Seon-Kyeong
Kang Jin-Yong
Kim Jong-Min
Shin Eun-Jin
Moon Jong-HYun
Moon Jong-HYun
Kim Min-Ji
Lee Hyo-Lim
Jeong Hye-Rim
Heo Ho-Jin
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Abstract
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To evaluate the protective effect of Codium fragile on fine dust (PM2.5)-induced cytotoxicity, we investigated its antioxidant activity and cell protective effect on PM2.5-exposed cells. The 40% ethanolic extract of C. fragile showed the highest total phenolic content, whereas the water extract of C. fragile showed the highest total polysaccharide content.
The protective effect of the extracts on PM2.5-induced oxidative damage in nasal cavity (RPMI2650), lung (A549), brain (MC-IXC), hippocampus (HT-22), and microglia (BV-2) cells was evaluated by measuring the intracellular reactive oxygen species (ROS) content and cell viability. The results showed that the 40% ethanolic extract more efficiently inhibited ROS production than the water extract. In contrast, PM2.5-exposed cells treated with the water extract showed higher viability than those treated with the 40% ethanolic extract.
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KEYWORD
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Codium fragile, fine dust, cell protection
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